Category Archives: Kidney Disease

Categories Kidney Disease

Diabetes as a Cause of Kidney Disease

There are different types of kidney disease, and different ways that the kidneys can begin to fail. In some cases, the cause of disease in someone’s kidneys stems from genetic factors that are out of the control of the sufferer. But the vast majority of causes are things that a person has some control over.

One of the well-known conditions that can lead to kidney disease is diabetes, but not everyone understands how a diabetic condition might eventually produce problems with the kidneys. As blood flows to the kidneys, impurities are filtered out while the healthy, more useful material, such as protein or blood cells, continue through the blood stream. But as sugar levels in the blood increase, the kidneys find themselves filtering more and more material.

What eventually occurs is that protein cells, too, begin to “leak” into the kidneys and get discarded in the urine. This happens because as the kidneys find themselves working much harder to filter the blood properly, eventually they start wearing out, and will become permanently damaged if the process is not somehow reversed. In the early period, this condition is called microalbuminuria, and it’s at this stage — when extra protein starts showing up in the urine, indicating a problem — at which the process may be stopped. If it progresses to macroalbuminuria, a high level of protein, the kidneys are damaged enough that complete failure is the most likely result.

Regular testing of protein levels in the urine can help a diabetic guard against the development of this problem. But the best way to try to prevent kidney disease in diabetics is to keep the blood sugar levels carefully controlled, and to control blood pressure as much as possible. Diabetes may be a condition that is inevitable for some people, if their bodies are unable to produce enough insulin. But kidney disease as a result of diabetes doesn’t have to be equally inevitable.

(For more detailed information, check the American Diabetes Association.)

Categories Kidney Disease

Pomegranates and Kidney Disease – Natural Wins Again!

People who advocate for more natural, less chemically-oriented treatments for bodily ailments got a boost recently, from a study showing that kidney patients on dialysis fared better when they drank pomegranate juice. The oral presentation, “One Year of Pomegranate Juice Consumption Decreases Oxidative Stress, Inflammation and Incidence of Infections in Hemodialysis Patients,” was given on Thursday, November 18, 2010, at the American Society of Nephrology’s 43rd Annual Meeting and Scientific Exposition in Denver, Colorado, as a part of Renal Week 2010.

Several researchers in hospitals in Israel did a year-long study in which they gave some dialysis patients pomegranate juice before their dialysis treatment, while other patients took a placebo. The researchers discovered that those who drank the pomegranate juice showed reduced inflammation and “oxidative stress.” While these things don’t halt the kidney disease itself, they significantly reduce complications that often stem from dialysis itself.

Kidney patients tend to die more from infections or cardiovascular-related problems. So it’s no small matter that those who took the pomegranate juice were shown to end up with fewer infections. They also tended to have lower blood pressure and fewer cardiovascular problems. The juice also improved their lipid profile, and had good antioxidant properties.

The researchers caution that this doesn’t mean kidney dialysis patients should start guzzling pomegranate juice all day long. The juice does have some potassium in it, and patients with chronic kidney disease could suffer potassium overload, which could also be harmful to the kidneys.

But taking pomegranate juice and monitoring potassium levels carefully could provide one way of easing pressure on the kidneys and improving the health and longevity of kidney patients. Further clinical trials are needed, but this most recent study suggests these patients could really benefit from this natural, healthy remedy.

Categories Kidney Disease

Taking Your Blood Pressure Meds Can Improve Kidney Disease Outcomes

You’d think it would be completely straightforward. Since one of the things that sometimes results from kidney disease is higher blood pressure, a kidney disease sufferer with hypertension problems would naturally take their medication. But a recent report has suggested that one-third of these patients actually don’t maintain their blood pressure treatments.

Researchers from the University of Cincinnati and the Cincinnati Veterans Affairs (VA) Medical Center have just published a report that describes this problem. They took two years’ worth of data from 7,227 patients at the VA who had chronic kidney disease (CKD), and who also suffered from hypertension. And this was when they uncovered the astonishing fact that about thirty-three percent of these patients either didn’t take their blood pressure medications, or had what was described as “poor medication adherence.”

The consequence appears to be a twenty-three percent higher likelihood of a worse outcome for those CKD patients themselves, when it comes to the progression of the disease. Doctor Charuhas Thakar, associate professor at the university and chief of the renal division at the VA, points out that high blood pressure is “probably the most important modifiable risk factor in chronic kidney disease.” This means that if patients are able to regulate their blood pressure and reduce the strain on the kidneys, they can do much better at improving their kidney health and, incidentally, lowering medical costs.

The report has just been published in the November 2nd online edition of the American Journal of Nephrology. Doctor Thakar points out that the results of this analysis need further confirmation, since all of this data came only from one place. But certainly this news suggests that people with CKD should not neglect their blood pressure medication if they suffer from hypertension.

(Further reading: UC Academic Health Center News Release, November 3, 2010)

Categories Kidney Disease

Diabetes Drug and Polycystic Kidney Disease

It’s well known that there’s a relationship between kidney disease and diabetes, but usually that connection is thought of as a causal one. That is, people with diabetes are at higher risk of developing kidney disease, because high glucose levels and high blood pressure can damage the kidneys. But now researchers from Indiana University-Purdue University Indianapolis, along with fellow researchers from the Mayo Clinic, have uncovered a connection between the two that’s a bit more positive.

Polycystic Kidney Disease (PKD) is somewhat different from other types of kidney disease in that it is caused by genetic factors. These lead to the growth of cysts in the kidneys, gradually reducing kidney function. But the researchers have now discovered that pioglitazone, a substance that treats diabetes by making the body more sensitive to insulin, does other things as well. One of those is to inhibit what is called a “chloride channel.”

This made the researchers sit up and take notice, since excessive chloride and water, which helps kidney cysts expand and multiply, is a characteristic of PKD. Pioglitazone is already approved for use for other conditions, and has a “good safety profile,” according to researcher Bonnie L. Blazer-Yost. This drug may be just what is needed to treat PKD and stop cyst progression, because at the moment, there are few other options for treating PDK.

Blazer-Yost and her other colleagues have published their paper in the online medical journal, PPAR Research. They hope that human trials for the use of this drug on PKD can be conducted in the not-too-distant future. It could mean real hope for effective treatment for many who have no other realistic hope at the moment.

(Further reading: Medical News Today, November 15, 2010)

Categories Health, Kidney Disease, Kundan Kidney Care Centre, Risk Factors

Pain Killers Bad for Kidneys, Worse for CKD

Do you pop pills at the slightest pain? If you are a pill-popper here is something you should know about analgesics also known as pain killers. They may relieve your pain but may be harming a vital organ in your body: your kidneys.  Even worse is those analgesics further reduce blood flow to the kidney when a person suffers from Chronic Kidney Disease (CKD).

How can the use of analgesics hurt the kidneys? The long term use of ibuprofen, naproxen sodium and other higher dose aspirin can cause chronic interstitial nephritis. For this reason, over the counter (OTC) pain relievers should not be used for more than 10 days and fever reducers for more than three days. This is clearly indicated in the warning labels of OTC analgesics. OTC analgesics include aspirin, acetaminophen, ibuprofen, naproxen sodium and ketoprofen.  Prescription analgesics are also available, and are usually stronger than OTC ones.

Additionally, analgesics and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) have been known to contribute to gastrointestinal bleeding and stomach ulcers. The use of NSAIDs also increase the risk of heart attack and stroke. NSAIDs are a group of pain relievers that include ibuprofen, naproxen sodium and ketoprofen.

It is strongly recommended that analgesics be used as prescribed by your doctor, or as stated on the label for OTC drugs; they should be taken at the lowest dose; and used for a short period.

Those with reduced kidney functions are not recommended to take higher dose aspirin and NSAIDs. If necessary, kidney patients should take NSAIDs under a doctor’s care. NSAIDs also have contra-indications for people with heart disease, liver disease, high blood pressure and those over 65. These pills increase the risk of kidney failure and cause progressive kidney damage.

Meanwhile, acetaminophen is the recommended analgesic for kidney patients. Aspirin is not recommended because it acts as a “blood thinner” and may cause bleeding complications. Patients on regular acetaminophen use should be supervised by their doctors. Alcohol should be avoided while on this medication.

The good news is kidney disease caused by the use of analgesics is PREVENTABLE! Here are some guidelines on how to use analgesics without harming your kidneys: Remember what was earlier said about prolonged use? Well OTC analgesics should not be used for more than 10 days for pain, and more than 3 days for fever. Drink at least eight glasses of fluids daily when taking analgesics, and avoid drinking alcohol. Analgesics with a mixture of painkillers and caffeine in one pill should be avoided. These can drastically damage the kidneys. Read the warning labels for all OTC analgesics. Those with underlying medical conditions like high blood pressure, kidney or liver diseases should take NSAIDs under the doctor’s care.  Last but not least, your doctor should be aware of all the medications you’re taking.

Categories Kidney Disease

More Detailed Blood Test may one day predict Kidney Disease

An American medical study spanning several generations may have inadvertently discovered significant blood markers that will one day help predict whether a person will experience Chronic Kidney Disease (CKD). The Framington Heart Study has been conducted since 1948 by the National Heart, Lung, and Blood Institute in Framington, Massachusetts. And some unexpected results that relate to CKD were published in theJournal of the American Society of Nephrology on October 21, 2010.

A new blood test for kidney disease?

The main test currently used to detect CKD is a test for creatinine in the blood. Unfortunately, though, creatinine only noticeably accumulates after the kidneys have already lost much of their function. If the new study’s results can be reproduced and further validated, they will provide ways of detecting CKD much earlier, meaning treatment can also begin earlier, thereby possibly saving the kidneys and preventing further damage.

The 2,300 study participants gave blood samples between 1995 and 1998, with normal kidney function. The odd thing was that since the study was mainly concerned with the heart, the focus was not at first on kidney disease at all. Yet when 9.5 percent of participants had developed CKD within a decade, with another eight percent having reduced kidney function, researchers examined six blood markers from the original samples to check for correlations. Two of these – homocysteine, which builds proteins, and aldosterone, dealing with how kidneys handle salt, had elevated levels, as did B-type natriuretic peptide, which also can indicate heart damage.

This doesn’t mean doctors can now simply test for these markers and immediately predict CKD. For one thing, the study must be replicated, widening beyond the largely European-descended group originally tested. But if these results hold true in future clinical studies, they may provide a way both of testing early for CKD, and taking steps to prevent and treat it.

(Further reading: Times of India, October 22, 2010; Medscape Today, October 21, 2010; My Health News Daily, October 21, 2010)

Categories Kidney Disease, Kundan Kidney Care Centre, Risk Factors

Kidney Disease and St. Patrick’s Day

Four Leaf Clover 068The month of March brings some interesting coincidences for many people with full-blown kidney disease or kidneys that are at risk. March is designated as National Kidney Month in the United States, or Kidney Health Month in Canada. March 10th is also World Kidney Day. And especially in North America, March 17th is celebrated as St. Patrick’s Day. The question is whether that celebration contradicts the message of the rest of the month, about kidney disease.

That depends how you celebrate the day. Although St. Patrick’s Day ostensibly honors the priest who brought Catholicism to Ireland, many people use it as an excuse to overindulge another activity unfairly associated with that country: the excessive drinking of alcohol. Such overindulgence is worrisome even for the health of people with undamaged kidneys. But for those who are already at some stage of kidney disease, excessive alcohol consumption can bring serious harm.

The symptoms of kidney disease often don’t show up until the kidneys are already compromised. So don’t assume that you have no kidney problems, just because you have no symptoms thus far. If you tend to over-drink, you’re already creating risks for kidney disease. For example, more than two drinks a day can raise the blood pressure, and the carbohydrate overload may lead to obesity and diabetes. All are well-known precursors to kidney problems. And the extra urination and interference with blood chemistry can make the kidneys unable to maintain the chemical balances they need.

With all this in mind, it’s undoubtedly best for a kidney patient not to over-drink on St. Patrick’s Day. But does that mean you can’t celebrate at all? You should decide what you really want out of this day. Do you regard it simply as an excuse to get drunk — or does it have other associations you could concentrate on?

Kidney patients already know that if they attend parties, or meet people at a pub or restaurant, they will retain certain dietary restrictions. Good friends and family should always be willing to accommodate a friend whose health is at risk. After all, it’s still possible to have a lot of fun wearing the green, going to a St. Patrick’s Day parade, and attending other activities. And following a kidney-healthy diet, you can still create special meals.

Despite some people’s belief, excessive drinking isn’t the only way to celebrate St. Patrick’s Day. Have fun with your friends on the day, but remember that no celebration should ever require you to risk your health or life.

 

Categories Kidney Disease, Risk Factors

Decrease in Diabetes-related Dialysis: Good News? Not so Fast.

The Centers for Disease Control and Prevention (CDC) has just released a report on the rates of End-Stage Renal Disease (ESRD) in persons diagnosed with diabetes. ESRD is the stage of kidney failure where the only possible treatment is either dialysis or a transplant, and according to this report, the rates of ESRD among diabetics wentdown thirty-five percent between 1996 and 2007. That’s good news — sort of. But unfortunately, there’s more to the story than that apparent decline.

The problem is that the number of people with ESRD actually went up over that period. In 1996, a total of 32,716 began ESRD treatments, while in 2007, that number had risen to 48,712. The only reason the total percentages were lower is that the number of patients diagnosed with diabetes skyrocketed even more over that decade. So while it’s a good thing that a lower percentage of diabetics are ending up with ESRD — at the moment, anyway — there are still more people with drastic kidney failure than there used to be.

This means that nobody should pat themselves on the back. Steps still need to be taken to reduce and ultimately prevent the incidence of diabetes, and there is still a clear connection between diabetes and kidney disease. The writers of the CDC report speculate that the lower percentage of diabetic ESRD sufferers may be due to better treatments for kidney problems, or some extra attention to risk factors.

But the CDC report points out that the primary risk factors still need considerable attention. The report writers provide a disturbing list:

In addition to diabetes and hypertension, risk factors for kidney disease include cardiovascular disease, obesity, elevated cholesterol, increasing age, and a family history of kidney disease.

While it’s good news that a slightly lower percentage of diabetics are ending up with ESRD, the underlying causes are still there, and still need urgent attention.

(Further Reading: Centers for Disease Control and PreventionMedPage Today;Bloomburg Businessweek – HealthDay)

Categories Kidney Disease, Kundan Kidney Care Centre, Risk Factors

What Teenagers with Kidney Diseases Should Know about Lipids

Being a teenager is not easy. Teenagers deal with peer pressure, an increasing need for more independence, changes in the body, relationship issues (with parents, teachers and friends), among others. Teenagers are more worried about what to wear in the school dance than they would be about lipids! However, teenagers with Chronic Kidney Diseases have a higher risk of developing lipid and heart problems and should be aware of them to remain healthy and continue with activities they enjoy. It is important for teenagers to know about lipids!

So what are lipids? They are simply the fats in the bloodstream of your body. The common type is called cholesterol which the body makes and comes from foods like meats, poultry (eggs and chicken), and dairy (milk, cheeses, ice cream). Fruits, vegetables and grains are cholesterol free. Teenagers should keep in mind that there are good and bad cholesterols.

There are three major types of lipids: Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) and the triglycerides. LDL is considered the bad cholesterol and is most likely to clog blood vessels and prevent the smooth blood flow in the system. HDL, on the other hand, is the good type of cholesterol which transports cholesterol away from the heart and blood and then back to the liver. From there, the cholesterol breaks down and sent to different parts of the body. Meanwhile, triglycerides are the stored fat in the body. High triglycerides do not clog blood vessels but may lead to diabetes or high blood sugar and can cause pancreas disorder.

LDL builds up in the blood results to the formation of plaque (fatty deposits) in the walls of the arteries. Plaque makes the arteries thicker, harder and narrower which decreases blood flow. Hardening of arteries in the heart leads to a heart attack or stroke.

People should always maintain a healthy level of cholesterol to prevent hardening of the arteries, high blood sugar or disorder of the pancreas. For teenagers the healthy levels of lipids are the following: total cholesterol is less than 200, LDL is less than 130, HDL is above 40, triglycerides are less than 150.  Doctors measure blood lipids through tests.  Haemodialysis patients are advised to have the lipid tests before dialysis while peritoneal dialysis patients are advised to
have the test in the morning. Another way to checks for healthy lipids is through the non-HDL test where the doctor subtracts the HDL from the total cholesterol. Lipids should be checked yearly or about 2 -3 months after a change in treatment.

Unhealthy lipids are caused by obesity, history of cholesterol problems or heart disease, diet high in saturated fats and cholesterol, not having enough exercise and excessive alcohol. To improve unhealthy levels just do the opposite of everything that’s causing it! Lose excess weight, follow a low-fat and low cholesterol diet, exercise regularly and minimize alcohol intake.

Teenagers will find it helpful to discuss what they have learned about lipids with their parents, and keep the communication line open especially with CKD issues. It is never easy living with a disease, and it complicates matters when hormones are changing. But awareness is key to remain healthy and continue with activities you enjoy as a teenager.*

Categories Kidney Disease

The Role of Oxygen in Kidney Disease Symptoms

Thinking of the internal organs in isolation, one may not suspect loss of oxygen to be one a major factor in kidney disease. But the interconnection of bodily systems means that a problem starting in one organ can have far-reaching and surprising effects in others. A lack of oxygen is one problem that can begin with the kidneys, but go on to affect the lungs and brain as well.

Kidneys produce a hormone called erythropoietin that signals the production of red blood cells. If the kidneys are failing, they create less of this hormone, meaning the body produces lower numbers of these cells. And since those cells carry oxygen, the body eventually suffers from anemia, a lack of oxygen.

One sign of oxygen starvation may be weary muscles. These rely on the oxygen carried by red blood cells, so if they get less of this vital fuel, they work less efficiently. A person may experience increased fatigue long before he has any idea he has kidney disease. The lungs are another area that might be affected. If the body is starved of oxygen, this can lead to shortness of breath. The lungs can’t take enough oxygen into the cells reaching the lungs, nor can those cells expel enough carbon dioxide. Eventually, as well as causing shortness of breath, this builds up acidity in the system.

The most surprising symptoms of kidney disease and oxygen starvation, though, may appear in the brain. Without enough oxygen, a person’s concentration can be affected. She may become dizzy. There could even be difficulty in remembering things.

People associate kidney disease with more obvious signs: back ache or a change in urine frequency and color. But because of the interconnected bodily systems, kidney disease may be signalled as much by dizziness or fatigue from a lack of oxygen as by painful urination. Keeping an eye on the body’s complete general health is essential to the early detection of kidney disease.

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